CD4 T cell responses to influenza infection

被引：135

作者：

Brown, DM ^{[1
]}

Román, E ^{[1
]}

Swain, SL ^{[1
]}

机构：

[1] Trudeau Inst Inc, Saranac Lake, NY 12983 USA

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 03期

关键词：

CD4 T cells; influenza; IFN-gamma; memory T cells; cytotoxicity;

D O I：

10.1016/j.smim.2004.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-gamma, IL-2 and TNF-alpha and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：171 / 177

页数：7

相关论文

共 54 条

[1]

Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2]

AHMED R, 1999, FUNDAMENTAL IMMUNOLO

[3]

ALLAN W, 1990, J IMMUNOL, V144, P3980

[4]

Phenotypic analysis of antigen-specific T lymphocytes [J].

Altman, JD ;

Moss, PAH ;

Goulder, PJR ;

Barouch, DH ;

McHeyzerWilliams, MG ;

Bell, JI ;

McMichael, AJ ;

Davis, MM .

SCIENCE, 1996, 274 (5284) :94-96

[5]

Reliable generation and use of MHC class II:: γ2afc multimers for the identification of antigen-specific CD4+ T cells [J].

Arnold, PY ;

Vignali, KM ;

Miller, TB ;

La Gruta, NL ;

Cauley, LS ;

Haynes, L ;

Adams, PS ;

Swain, SL ;

Woodland, DL ;

Vignali, DAA .

JOURNAL OF IMMUNOLOGICAL METHODS, 2002, 271 (1-2) :137-151

[6]

Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[7]

Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection [J].

Baumgarth, N ;

Kelso, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (09) :2189-2197

[8]

Compromised influenza virus-specific CD8+-T-Cell memory in CD4+-T-cell-deficient mice [J].

Belz, GT ;

Wodarz, D ;

Diaz, G ;

Nowak, MA ;

Doherty, PC .

JOURNAL OF VIROLOGY, 2002, 76 (23) :12388-12393

[9]

TRANSGENIC MICE LACKING CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED T-CELLS HAVE DELAYED VIRAL CLEARANCE AND INCREASED MORTALITY AFTER INFLUENZA-VIRUS CHALLENGE [J].

BENDER, BS ;

CROGHAN, T ;

ZHANG, LP ;

SMALL, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1143-1145

[10]

ENVIRONMENTAL MODULATION OF THE AUTONOMY OF CYTOTOXIC T-LYMPHOCYTES [J].

BODMER, H ;

OBERT, G ;

CHAN, S ;

BENOIST, C ;

MATHIS, D .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (07) :1649-1654

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