The core of bluetongue virus binds double-stranded RNA

被引：18

作者：

Diprose, JM

Grimes, JM

Sutton, GC

Burroughs, JN

Meyer, A

Maan, S

Mertens, PPC

Stuart, DI

机构：

[1] Wellcome Trust Ctr Human Genet, Div Struct Biol, Oxford OX3 7BN, England

[2] Univ Oxford, Oxford Ctr Mol Sci, Oxford OX1 3PT, England

[3] AFRC, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 18期

关键词：

D O I：

10.1128/JVI.76.18.9533-9536.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA. This may represent a deliberate strategy to sequester dsRNA released from damaged particles to prevent host cell shutoff.

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页码：9533 / 9536

页数：4

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