Polymer conjugates as anticancer nanomedicines

被引：1613

作者：

Duncan, Ruth ^{[1
]}

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Ctr Polymer Therapeut, Cardiff CF10 3XF, Wales

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 09期

关键词：

D O I：

10.1038/nrc1958

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transfer of polymer - protein conjugates into routine clinical use, and the clinical development of polymer-anticancer-drug conjugates, both as single agents and as components of combination therapy, is establishing polymer therapeutics as one of the first classes of anticancer nanomedicines. There is growing optimism that ever more sophisticated polymer-based vectors will be a significant addition to the armoury currently used for cancer therapy.

引用

页码：688 / 701

页数：14

共 161 条

[41] DEGRADATION OF SIDE-CHAINS OF N-(2-HYDROXYPROPYL)METHACRYLAMIDE CO-POLYMERS BY LYSOSOMAL THIOL-PROTEINASES [J].

DUNCAN, R ;

CABLE, HC ;

LLOYD, JB ;

REJMANOVA, P ;

KOPECEK, J .

BIOSCIENCE REPORTS, 1982, 2 (12) :1041-1046

[42] TARGETING OF N-(2-HYDROXYPROPYL)METHACRYLAMIDE CO-POLYMERS TO LIVER BY INCORPORATION OF GALACTOSE RESIDUES [J].

DUNCAN, R ;

KOPECEK, J ;

REJMANOVA, P ;

LLOYD, JB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 755 (03) :518-521

[43] TYROSINAMIDE RESIDUES ENHANCE PINOCYTIC CAPTURE OF N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS [J].

DUNCAN, R ;

CABLE, HC ;

REJMANOVA, P ;

KOPECEK, J ;

LLOYD, JB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 799 (01) :1-8

[44]

Duncan R., 2005, Polymeric Drug Delivery Systems, P27

[45]

Duncan R., 2003, HDB ANTICANCER DRUG, P239

[46]

Fang J, 2002, CANCER RES, V62, P3138

[47] Cancer nanotechnology: Opportunities and challenges [J].

Ferrari, M .

NATURE REVIEWS CANCER, 2005, 5 (03) :161-171

[48]

FLAHERTYL, 2005, P AN M AM SOC CLIN, P7562

[49] THE CLINICAL EFFICACY OF POLY(ETHYLENE GLYCOL)-MODIFIED PROTEINS [J].

FUERTGES, F ;

ABUCHOWSKI, A .

JOURNAL OF CONTROLLED RELEASE, 1990, 11 (1-3) :139-148

[50] HPMA copolymers platinates containing dicarboxylato ligands.: Preparation, characterisation and in vitro and in vivo evaluation [J].

Gianasi, E ;

Buckley, RG ;

Latigo, J ;

Wasil, M ;

Duncan, R .

JOURNAL OF DRUG TARGETING, 2002, 10 (07) :549-556

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