Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods

被引：108

作者：

Gu, Sihao ^{[1
]}

Li, Ling ^{[1
]}

Huang, Hai ^{[2
]}

Wang, Bing ^{[1
,3
]}

Zhang, Tong ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Sch Pharm, Expt Ctr Teaching & Learning, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China

[2] Fudan Univ, Sch Pharm, Expt Teaching Ctr Pharmaceut Sci, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Materia Med, Ctr Pharmaceut Res, 501 Hai Ke Rd, Shanghai 201203, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Atractylodes macrocephala Koidz; essential oils; atractylone; processing methods; GC; MS; pharmacodynamic effect; PERFORMANCE LIQUID-CHROMATOGRAPHY; CHEMICAL-COMPOSITION; ATRACTYLENOLIDE-I; VOLATILE COMPOUNDS; TIGHT JUNCTIONS; EXTRACTION; PHASE; CONSTITUENTS; COMPONENTS; RHIZOMA;

D O I：

10.3390/molecules24162956

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Atractylodes macrocephala Koidz. has been used as an invigorating spleen drug for eliminating dampness and phlegm in China. According to recent researches, different processing methods may affect the drug efficacy, so we collected A. macrocephala from the Zhejiang Province, produced with different processing methods, crude A. macrocephala (CA) and bran-processed A. macrocephala (BA), then analyzed its essential oils (EOs) by GC/MS. The results showed 34 components representing 98.44% of the total EOs of CA were identified, and 46 components representing 98.02% of the total EOs of BA were identified. Atractylone is the main component in A. macrocephala. Compared with CA, BA has 46 detected compounds, 28 of which were identical, and 6 undetected compounds. Pharmacodynamic results revealed that the EOs of CA and atractylone exhibited more effective anticancer activity in HepG2, MCG803, and HCT-116 cells than the EOs of BA; while the EOs of BA exhibited simple antiviral effect on viruses H3N2, both the EOs and atractylone show anti-inflammatory activity by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in ANA-1 cells.

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页数：14

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