Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices

被引：14

作者：

Arai, I

Shimazoe, T

Shibata, S

Inoue, H

Yoshimatsu, A

Watanabe, S

机构：

[1] KYUSHU UNIV 62,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 81282,JAPAN

[2] WASEDA UNIV,SCH HUMAN SCI,DEPT PHARMACOL,TOKOROZAWA,SAITAMA 359,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 73卷 / 03期

关键词：

methamphetamine-induced sensitization; striatal dopamine release; metabotropic glutamate receptor;

D O I：

10.1254/jjp.73.243

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the roles of metabotropic glutamate receptors in methamphetamine (MAP)induced sensitization of dopamine (DA) release from striatal slices. Rats were first treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. After a 6-day withdrawal, DA release from striatal slices evoked by +/--1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD) was measured. trans-ACPD-induced DA release was significantly enhanced in MAP-sensitized rats, but the inactive form of trans-ACPD (IR,3S-ACPD) did not enhance DA release. The active form of trans-ACPD (1S,3R-ACPD) (0.1 mM)-evoked DA release was attenuated by treatment with 0.4 mM RS-alpha-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor antagonist. The present results suggest that metabotropic glutamate receptors play an important role in expression of MAP-induced sensitization.

引用

页码：243 / 246

页数：4

共 14 条

[1]

Arai I, 1996, BRAIN RES, V729, P277, DOI 10.1016/S0006-8993(96)00581-1

[2] COACTIVATION OF D1 AND D2 DOPAMINE-RECEPTORS IS REQUIRED FOR LONG-TERM SYNAPTIC DEPRESSION IN THE STRIATUM [J].