Hippocampal upregulation of the cyclooxygenase-2 gene following neonatal clomipramine treatment (a model of depression)

被引：43

作者：

Cassano, P. ^{[1
]}

Hidalgo, A. ^{[1
]}

Burgos, V. ^{[1
]}

Adris, S. ^{[1
]}

Argibay, P. ^{[1
]}

机构：

[1] Hosp Italiano Buenos Aires, Inst Ciencias Basicas & Med Expt, Brain Res Unit, RA-4240 Buenos Aires, DF, Argentina

来源：

PHARMACOGENOMICS JOURNAL | 2006年 / 6卷 / 06期

关键词：

COX-2; clomipramine; depressive disorders;

D O I：

10.1038/sj.tpj.6500385

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although a putative role has been attributed to inflammation in the pathogenesis of depressive disorders, the relationship of prostaglandins, known mediators of inflammation, and depression has not been elucidated. Clomipramine is an antidepressive drug with a pro-depressive paradoxical effect in adult rats when administrated neonatally. Using this effect as a model of depression, we investigated the differential expression of the cyclooxygenase (COX-2) gene in rat brains. Rats injected neonatally with clomipramine showed depressive-like symptoms in adulthood, as well as decreased levels of the brain-derived neurotrophic factor (BDNF) and a quantitative differential expression of the COX-2 gene (Real Time PCR) and protein (immunohistochemistry) in the hippocampus. As evidenced, the relationship between a key enzyme in the prostaglandin synthesis and biological and behavioral depression-like changes opens an interesting line of investigation regarding the molecular bases of depression and its potential treatment through immunomodulatory drugs.

引用

页码：381 / 387

页数：7

共 51 条

[21] Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E2 production and neurodegeneration in cortical and hippocampal cell cultures [J].