Preparation of the stereoisomers of 2-cyanocycloalkanols by lipase-catalysed acylation

被引：21

作者：

Forro, E

Lundell, K

Fulop, F

Kanerva, LT

机构：

[1] UNIV TURKU,DEPT CHEM,FIN-20014 TURKU,FINLAND

[2] UNIV TURKU,DEPT BIOMED,FIN-20014 TURKU,FINLAND

[3] ALBERT SZENT GYORGYI MED UNIV,DEPT PHARMACEUT CHEM,H-6701 SZEGED,HUNGARY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 18期

关键词：

D O I：

10.1016/S0957-4166(97)00376-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiopure (1R,2R)-, (1S,2S)-, (1S,2R)- and (IR,2S)-2-cyanocyclopentanol and -cyclohexanol, isomers were prepared through the Pseudomonas cepacia lipase-catalysed acetylation of the racemic cis and trans compounds with vinyl acetate in diisopropyl ether. The quasi-irreversible nature of acylations with 2,2,2-trifluoroethyl esters is evident. (C) 1997 Elsevier Science Ltd.

引用

页码：3095 / 3099

页数：5

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