FACILE CONVERSION OF EPOXIDES TO BETA-HYDROXY NITRILES UNDER ANHYDROUS CONDITIONS WITH LITHIUM CYANIDE

被引：46

作者：

CIACCIO, JA

STANESCU, C

BONTEMPS, J

机构：

[1] Department of Chemistry, Fordham University, Bronx

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)91639-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized epoxides are easily and efficiently converted to beta-hydroxy nitriles in good yield with high regio- and stereoselectivity upon treatment with lithium cyanide in refluxing anhydrous THF. The conditions described permit a one-pot conversion of epoxide to 1,3-amino alcohol via hydride reduction of the nitrile.

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页码：1431 / 1434

页数：4

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