A high body mass index protects against femoral neck osteoporosis in healthy elderly subjects

被引:122
作者
Barrera, G
Bunout, D
Gattás, V
de la Maza, MP
Leiva, L
Hirsch, S
机构
[1] Univ Chile, Inst Nutr & Food Technol, Santiago, Chile
[2] Univ Chile, Fac Med, Santiago 7, Chile
关键词
osteoporosis; elderly; body mass index; body composition;
D O I
10.1016/j.nut.2004.05.014
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
OBJECTIVE: In a large sample of elderly subjects, we assessed the possible protective effect of obesity on the development of osteoporosis. METHODS: Healthy subjects 70 y or older and of low socioeconomic level were studied. Bone mineral density was measured in the femoral neck by using a Lunar Prodigy double beam densitometer and compared measurements with appropriate standards. Osteoporosis was defined according to criteria of the World Health Organization (WHO). Body weight and height were recorded simultaneously, and body mass index (BMI) was calculated as weight (kg) divided by height (m(2)). Age-adjusted odds ratios for femoral osteoporosis were calculated for WHO-proposed BMI ranges in women and men, with an odds of one for a BMI below 25 kg/m(2). RESULTS: Eight hundred forty-five subjects.(615 women and 230 men; mean age, 75 +/- 4.4 y) were studied. Mean BMI was 28.1 +/- 4.7 kg/m(2). twenty five percent of women and 11% of men had osteoporosis (P < 0.001). Forward stepwise multiple regression analysis showed BMI to be the best independent predictor of bone mineral density in women and men. The age-adjusted odds ratios for femoral osteoporosis were 0.34 (95% confidence interval [CI], 0.21 to 0.55) and 0.13 (95% CI, 0.04 to 0.43) for women and men with a BMI between 25 and 30 kg/m(2), respectively. The odds ratios for women and men with a BMI between 30 and 35 kg/m(2) were 0.21 (95% CI, 6.11 to 0.39) and 0.09 (95% CI, 0.01 to 0.67), respectively. CONCLUSIONS: This study confirms the protective effect of a high BMI on femoral neck bone mineral density among elderly subjects. The risk for osteoporosis among men and women with a BMI above 30 kg/m(2) was approximately 33% compared with subjects with a normal BMI. (C) Elsevier Inc. 2004.
引用
收藏
页码:769 / 771
页数:3
相关论文
共 22 条
[1]  
Albala C, 1996, INT J OBESITY, V20, P1027
[2]   The impact of nutritional supplementation and resistance training on the health functioning of free-living Chilean elders:: Results of 18 months of follow-up [J].
Bunout, D ;
Barrera, G ;
de la Maza, P ;
Avendaño, M ;
Gattas, V ;
Petermann, M ;
Hirsch, S .
JOURNAL OF NUTRITION, 2001, 131 (09) :2441S-2446S
[3]   Fat or lean tissue mass: Which one is the major determinant of bone mineral mass in healthy postmenopausal women? [J].
Chen, Z ;
Lohman, TG ;
Stini, WA ;
Ritenbaugh, C ;
Aickin, M .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (01) :144-151
[4]   Leptin: cutting the fat off the bone [J].
Cock, TA ;
Auwerx, J .
LANCET, 2003, 362 (9395) :1572-1574
[5]   Effect of calcium and vitamin D supplementation on bone, density in men and women 65 years of age or older [J].
DawsonHughes, B ;
Harris, SS ;
Krall, EA ;
Dallal, GE .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (10) :670-676
[6]   Leptin resistance - or why leptin fails to work in obesity [J].
El-Haschimi, K ;
Lehnert, H .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2003, 111 (01) :2-7
[7]   Body size and hip fracture risk in older women: A prospective study [J].
Ensrud, KE ;
Lipschutz, RC ;
Cauley, JA ;
Seeley, D ;
Nevitt, MC ;
Scott, J ;
Orwoll, ES ;
Genant, HK ;
Cummings, SR .
AMERICAN JOURNAL OF MEDICINE, 1997, 103 (04) :274-280
[8]  
Feskanich D, 1999, AM J CLIN NUTR, V69, P74
[9]   Differences in body composition between female geriatric hip fracture patients and healthy controls: Body fat is more important as explanatory factor for the fracture than body weight and lean body mass [J].
Galvard, H ;
Elmstahl, S ;
Elmstahl, B ;
Samuelsson, SM ;
Robertsson, E .
AGING CLINICAL AND EXPERIMENTAL RESEARCH, 1996, 8 (04) :282-286
[10]   Leptin controls bone formation through a hypothalamic relay [J].
Karsenty, G .
RECENT PROGRESS IN HORMONE RESEARCH, VOL 56, 2001, 56 :401-415