Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances

被引:16
作者
Bantsiele, Guy-Bernard [2 ]
Bentue-Ferrer, Daniele [2 ]
Saikali, Stephan [3 ]
Laviolle, Bruno [4 ]
Bourin, Michel [1 ]
Reymann, Jean-Michel [2 ]
机构
[1] Fac Med Nantes, Pharmacol Lab, F-44035 Nantes, France
[2] Fac Med Rennes, Lab Pharmacol Expt & Clin, Fac Med Rennes, CS34317, F-35043 Rennes, France
[3] Fac Med Rennes, Lab Anatomopathol, CS34317, F-35043 Rennes, France
[4] CHU Pontchaillou, Ctr Invest Clin, INSERM 0203, F-35033 Rennes, France
关键词
Antidepressants; Cardiac arrest; Cerebral ischemia; Elevated plus-maze; Ethological parameters; Forced swimming test; GLOBAL CEREBRAL-ISCHEMIA; FORCED SWIMMING TEST; TRANSIENT FOREBRAIN ISCHEMIA; MONOAMINE OXIDASE-A; POSTSTROKE DEPRESSION; CARDIAC-ARREST; REVERSIBLE INHIBITOR; RODENT MODELS; ANIMAL-MODELS; ANXIETY;
D O I
10.1016/j.bbr.2009.02.022
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The aim of this study was to examine the psychopharmacological effects of antidepressants on post-ischemic rats. Global transient cerebral ischemia was performing with the four-vessels occlusion method. Locomotor activity, neurological scores and activity during the 20 min forced swimming test (FST) session were comparatively evaluated in sham-operated and ischemic animals. Three doses of four antidepressants or saline were then intraperitoneally administered 23.5, 5 and 1 h before the 5 min FST session, and 0.5 h before the elevated plus-maze (EPM). Histological quantification of neuronal loss was performed at the end of the experiments. Results show that before treatment, ischemic animals present significantly greater spontaneous motor activity, a neurological score and an immobility time in the 20 min FST lower than sham-operated animals. After treatment, compared to the saline group, we show an antidepressant-like activity in the FST with all the molecules, except with the fluvoxamine, and an anxiolytic-like effect in the EPM, with at least one dose of each compounds. The observed effect is very similar according to whether or not the animals were ischemic, with a tendency to react more important for ischemic animals versus sham-operated. This difference is significant in the FST for the immobility time and in the EPM for the ratio of distance, of time, of number of entrances and non-protected head dips with the 45 mg dose of milnacipran. These results demonstrate that even though global transient cerebral ischemia induces important cerebral lesions, it modifies little the effects of the different antidepressants, whatever their primary pharmacological target, with a particular effectiveness with the dual serotonin and norepinephrine reuptake inhibitor milnacipran. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:265 / 271
页数:7
相关论文
共 49 条
[31]   THE USE OF LOCOMOTOR-ACTIVITY AS A BEHAVIORAL SCREEN FOR NEURONAL DAMAGE FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA IN GERBILS [J].
MILESON, BE ;
SCHWARTZ, RD .
NEUROSCIENCE LETTERS, 1991, 128 (01) :71-76
[32]   Time-dependent effects of global cerebral ischemia on anxiety, locomotion, and habituation in rats [J].
Milot, Marc R. ;
Plamondon, Helene .
BEHAVIOURAL BRAIN RESEARCH, 2009, 200 (01) :173-180
[33]   VALIDATION OF OPEN - CLOSED ARM ENTRIES IN AN ELEVATED PLUS-MAZE AS A MEASURE OF ANXIETY IN THE RAT [J].
PELLOW, S ;
CHOPIN, P ;
FILE, SE ;
BRILEY, M .
JOURNAL OF NEUROSCIENCE METHODS, 1985, 14 (03) :149-167
[34]  
Plamondon H, 2005, PHYSIOL BEHAV, V84, P543, DOI 10.1016/j.physbeh.2005.02.001
[35]   FUNCTIONAL, BEHAVIORAL, AND HISTOLOGICAL-CHANGES INDUCED BY TRANSIENT GLOBAL CEREBRAL-ISCHEMIA IN RATS - EFFECTS OF CINNARIZINE AND FLUNARIZINE [J].
POIGNET, H ;
BEAUGHARD, M ;
LECOIN, G ;
MASSINGHAM, R .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (05) :646-654
[36]  
PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
[37]   BEHAVIORAL DESPAIR IN RATS - NEW MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS [J].
PORSOLT, RD ;
ANTON, G ;
BLAVET, N ;
JALFRE, M .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (04) :379-391
[38]   DEPRESSION - NEW ANIMAL-MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS [J].
PORSOLT, RD ;
LEPICHON, M ;
JALFRE, M .
NATURE, 1977, 266 (5604) :730-732
[39]   NEW MODEL OF BILATERAL HEMISPHERIC ISCHEMIA IN THE UNANESTHETIZED RAT [J].
PULSINELLI, WA ;
BRIERLEY, JB .
STROKE, 1979, 10 (03) :267-272
[40]  
Rampello Liborio, 2005, Expert Opin Drug Saf, V4, P885, DOI 10.1517/14740338.4.5.885