Facile synthesis of completely protected enantiomerically pure alpha,alpha-disubstituted alpha-amino acids

被引：18

作者：

Westermann, B

Gedrath, I

机构：

[1] Universität-GH Paderborn, Fb. F. Chemie und Chemietechnik, 33098 Paderborn

来源：

SYNLETT | 1996年 / 07期

关键词：

amino acid; quaternary carbon centre; PLE-catalyzed saponification; peptide mimic;

D O I：

10.1055/s-1996-5545

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,alpha-Disubstituted alpha-amino acids are synthesized from readily availible beta-ketoesters by a three step procedure: Beckmann rearrangement, protection of the lactam followed by nucleophilic ring opening.

引用

页码：665 / +

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