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Plasticity of adult stem cells

被引：858
作者：
Wagers, AJ [1 ]
Weissman, IL
机构：
[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA
来源：
CELL | 2004年 / 116卷 / 05期
关键词：
D O I：
10.1016/S0092-8674(04)00208-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent years have seen much excitement over the possibility that adult mammalian stem cells may be capable of differentiating across tissue lineage boundaries, and as such may represent novel, accessible, and very versatile effectors of therapeutic tissue regeneration. Yet studies proposing such "plasticity" of adult somatic stem cells remain controversial, and in general, existing evidence suggests that in vivo such unexpected transformations are exceedingly rare and in some cases can be accounted for by equally unexpected alternative explanations.
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页码：639 / 648
页数：10
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