Get real in individual participant data (IPD) meta-analysis: a review of the methodology

被引：215

作者：

Debray, Thomas P. A. ^{[1
,2
]}

Moons, Karel G. M. ^{[1
,2
]}

van Valkenhoef, Gert ^{[3
]}

Efthimiou, Orestis ^{[4
]}

Hummel, Noemi ^{[5
]}

Groenwold, Rolf H. H. ^{[1
]}

Reitsma, Johannes B. ^{[1
,2
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[2] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dutch Cochrane Ctr, Utrecht, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[4] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece

[5] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

来源：

RESEARCH SYNTHESIS METHODS | 2015年 / 6卷 / 04期

关键词：

meta-analysis; IPD; evidence synthesis; review; RCT; non-randomized intervention studies; NRSI; cross-design; PATIENT DATA METAANALYSIS; ZERO-INFLATED POISSON; ADJUSTED INDIRECT COMPARISONS; RANDOM EFFECTS MODELS; CARE DECISION-MAKING; SURVIVAL-DATA; SYSTEMATIC REVIEWS; PROPORTIONAL-HAZARDS; AGGREGATE DATA; MULTIPLE IMPUTATION;

D O I：

10.1002/jrsm.1160

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Individual participant data (IPD) meta-analysis is an increasingly used approach for synthesizing and investigating treatment effect estimates. Over the past few years, numerous methods for conducting an IPD meta-analysis (IPD-MA) have been proposed, often making different assumptions and modeling choices while addressing a similar research question. We conducted a literature review to provide an overview of methods for performing an IPD-MA using evidence from clinical trials or non-randomized studies when investigating treatment efficacy. With this review, we aim to assist researchers in choosing the appropriate methods and provide recommendations on their implementation when planning and conducting an IPD-MA. (c) 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.

引用

页码：293 / 309

页数：17

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