A strategy for enhanced antibacterial activity against Staphylococcus aureus by the assembly of alamethicin with a thermo-sensitive polymeric carrier

被引：38

作者：

Dong, Ping ^{[1
,2
]}

Zhou, Yuan ^{[1
,2
]}

He, Weiwei ^{[1
,2
,3
]}

Hua, Daoben ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China

[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[3] Collaborat Innovat Ctr Radiol Med Jiangsu Higher, Suzhou 215123, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 05期

关键词：

GAMMA-RAY IRRADIATION; LIPOSOMAL POLYMYXIN-B; PSEUDOMONAS-AERUGINOSA; MECHANISM; MODEL; COPOLYMERS; PEPTAIBOL; INFECTION; PEPTIDES; EFFICACY;

D O I：

10.1039/c5cc07054f

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We demonstrate here a strategy for enhanced antibacterial activity against microbial strains by the assembly of antimicrobial peptides with a temperature-responsive polymeric carrier. The assembly complex was less toxic to human cells and more stable to enzymatic cleavage. This work may provide a promising drug delivery system for antimicrobial peptides.

引用

收藏

页码：896 / 899

页数：4

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