Mechanisms and Barriers in Cancer Nanomedicine: Adressing Challenges, Looking for Solutions

被引：288

作者：

Anchordoquy, Thomas J. ^{[1
]}

Barenholz, Yechezkel ^{[6
]}

Boraschi, Diana ^{[7
]}

Chorny, Michael ^{[8
]}

Decuzzi, Paolo ^{[9
]}

Dobrovolskaia, Marina A. ^{[10
]}

Farhangrazi, Z. Shadi ^{[11
,12
]}

Farrell, Dorothy ^{[13
]}

Gabizon, Alberto ^{[14
]}

Ghandehari, Hamidreza ^{[15
,16
,17
]}

Godin, Biana ^{[18
]}

La-Beck, Ninh M. ^{[19
,20
]}

Ljubimova, Julia ^{[21
,22
]}

Moghimi, S. Moein ^{[23
]}

Pagliaro, Len ^{[24
]}

Park, Ji-Ho ^{[25
]}

Peer, Dan ^{[26
,27
,28
]}

Ruoslahti, Erkki ^{[29
]}

Serkova, Natalie J. ^{[2
,3
,4
,5
]}

Simberg, Dmitri ^{[1
]}

机构：

[1] Univ Colorado Denver, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO 80045 USA

[2] Univ Colorado Denver, Sch Med, Dept Anesthesiol, Aurora, CO 80045 USA

[3] Univ Colorado Denver, Sch Med, Dept Radiat Oncol, Aurora, CO 80045 USA

[4] Univ Colorado Denver, Sch Med, Dept Radiol, Aurora, CO 80045 USA

[5] Univ Colorado Denver, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA

[6] Hebrew Univ Hadassah Med Sch, Lab Membrane & Liposome Res, IMRIC, IL-91120 Jerusalem, Israel

[7] CNR, Inst Prot Biochem, I-80131 Naples, Italy

[8] Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[9] Fondazione Ist Italiano Tecnologia, Lab Nanotechnol Precis Med, I-16163 Genoa, Italy

[10] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Nanotechnol Characterizat Lab, Frederick, MD 21702 USA

[11] Denver Technol Ctr, Biotrends Int, Greenwood, CO 80111 USA

[12] Univ Denver, Univ Coll, Denver, CO 80208 USA

[13] Natl Canc Inst, Natl Inst Hlth, Off Canc Nanotechnol Res, Bethesda, MD 20892 USA

[14] Hebrew Univ Sch Med, Inst Oncol, Shaare Zedek Med Ctr, IL-9103102 Jerusalem, Israel

[15] Univ Utah, Dept Pharmaceut, Salt Lake City, UT 84112 USA

[16] Univ Utah, Dept Pharmaceut Chem, Salt Lake City, UT 84112 USA

[17] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[18] Houston Methodist Res Inst, Dept Nanomedicine, Houston, TX 77030 USA

[19] Texas Tech Univ Hlth Sci Ctr, Sch Pharm, Dept Immunotherapeut, Abilene, TX 79601 USA

[20] Texas Tech Univ Hlth Sci Ctr, Sch Pharm, Dept Biotechnol, Abilene, TX 79601 USA

[21] Cedars Sinai Med Ctr, Nanomedicine Res Ctr, Ctr Comprehens Canc, Dept Neurosurgery, Los Angeles, CA 90048 USA

[22] Cedars Sinai Med Ctr, Nanomedicine Res Ctr, Ctr Comprehens Canc, Dept Biomed Sci, Los Angeles, CA 90048 USA

[23] Univ Durham, Sch Med Pharm & Hlth, Queens Campus, Stockton On Tees TS17 6BH, Durham, England

[24] Siva Therapeutics Inc, Austin, TX 78759 USA

[25] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

[26] Tel Aviv Univ, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel

[27] Tel Aviv Univ, Dept Immunol, IL-69978 Tel Aviv, Israel

[28] Tel Aviv Univ, Dept Mat Sci & Engn, IL-69978 Tel Aviv, Israel

[29] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

来源：

ACS NANO | 2017年 / 11卷 / 01期

关键词：

Diseases - Synthesis (chemical) - Nanoparticles - Drug delivery;

D O I：

10.1021/acsnano.6b08244

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Remarkable progress has recently been made in the synthesis and characterization of engineered nanoparticles for imaging and treatment of cancers, resulting in several promising candidates in clinical trials. Despite these advances, clinical applications of nanoparticle-based therapeutic/imaging agents remain limited by biological, immunological, and translational barriers. In order to overcome the existing status quo in drug delivery, there is a need for open and frank discussion in the nanomedicine community on what is needed to make qualitative leaps toward translation. In this Nano Focus, we present the main discussion topics and conclusions from a recent workshop: Mechanisms and Barriers in Nanomedicine. The focus of this informal meeting was on biological, toxicological, immunological, and translational aspects of nanomedicine and approaches to move the field forward productively. We believe that these topics reflect the most important issues in cancer nanomedicine.

引用

页码：12 / 18

页数：7

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