Enhancement of DNA vaccine potency in rhesus macaques by electroporation

被引：141

作者：

Otten, G

Schaefer, M

Doe, B

Liu, H

Srivastava, I

zur Megede, J

O'Hagan, D

Donnelly, J

Widera, G

Rabussay, D

Lewis, MG

Barnett, S

Ulmer, JB

机构：

[1] Chiron Corp, Vaccines Res, Emeryville, CA 94068 USA

[2] Genetron Inc, San Diego, CA USA

[3] So Res Inst, Frederick, MD USA

来源：

VACCINE | 2004年 / 22卷 / 19期

关键词：

DNA; electroporation; vaccine; HIV;

D O I：

10.1016/j.vaccine.2003.11.073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2489 / 2493

页数：5

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