Four cases of mumps were reported among 180 army recruits who had received MMR vaccine 16 days earlier. Mumps serology, salivary mumps IgM and PCR tests for the SH gene were performed on the 4 cases and on 5 control recruits who remained well. PCR products were sequenced and the sequences compared to those of wild type and vaccine strains of mumps. Further salivary mumps IgM tests were performed on the remaining 171 recruits. Mumps infection was confirmed in the 4 cases but not in the 5 controls. The controls had serological evidence of prior immunity. The SH gene sequence found in the 4 cases was wild type. Saliva tests identified 2 additional recruits with mumps IgM, one of whom had presented with suspected mumps 2 days before the MMR vaccine was given. Thus 6 (5 symptomatic and 1 asymptomatic) cases of mumps in army recruits recently receiving MMR vaccine were not due to the vaccine but to coincidental infection with wild-type mumps virus. The probable index case was revealed by salivary mumps IgM tests. This study highlights the importance of appropriate investigation of illness associated with MMR vaccination.
机构:
Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, EnglandUniv London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Wakefield, AJ
Murch, SH
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Murch, SH
Anthony, A
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Anthony, A
Linnell, J
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Linnell, J
Casson, DM
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Casson, DM
Malik, M
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Malik, M
Berelowitz, M
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Berelowitz, M
Dhillon, AP
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Dhillon, AP
Thomson, MA
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Thomson, MA
Harvey, P
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Harvey, P
Valentine, A
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Valentine, A
Davies, SE
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Davies, SE
Walker-Smith, JA
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Wu, L
Bai, Z
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机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Bai, Z
Li, Y
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机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Li, Y
Rima, BK
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机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Rima, BK
Afzal, MA
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机构:
Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, EnglandNatl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
机构:
Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, EnglandUniv London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Wakefield, AJ
Murch, SH
论文数: 0引用数: 0
h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Murch, SH
Anthony, A
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h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Anthony, A
Linnell, J
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Linnell, J
Casson, DM
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机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Casson, DM
Malik, M
论文数: 0引用数: 0
h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Malik, M
Berelowitz, M
论文数: 0引用数: 0
h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Berelowitz, M
Dhillon, AP
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h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Dhillon, AP
Thomson, MA
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h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Thomson, MA
Harvey, P
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h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Harvey, P
Valentine, A
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h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Valentine, A
Davies, SE
论文数: 0引用数: 0
h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
Davies, SE
Walker-Smith, JA
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h-index: 0
机构:Univ London Royal Free Hosp, Sch Med, Dept Med, Inflammatory Bowel Dis Study Grp, London NW3 2QG, England
机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Wu, L
Bai, Z
论文数: 0引用数: 0
h-index: 0
机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Bai, Z
Li, Y
论文数: 0引用数: 0
h-index: 0
机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Li, Y
Rima, BK
论文数: 0引用数: 0
h-index: 0
机构:Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England
Rima, BK
Afzal, MA
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, EnglandNatl Inst Biol Stand & Controls, Div Virol, Potters Bar 3QG, Herts, England