Cancer: pathological nuclear reprogramming?

被引：63

作者：

Goding, Colin R. ^{[1
]}

Pei, Duanqing ^{[2
]}

Lu, Xin ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Ludwig Inst Canc Res, Oxford OX3 7DQ, England

[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, South China Inst Stem Cell Biol & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 08期

关键词：

ACUTE MYELOID-LEUKEMIA; PLURIPOTENT STEM-CELLS; DNA DEMETHYLATION; XENOPUS-LAEVIS; IDH2; MUTATIONS; SOMATIC-CELLS; MOUSE; 5-HYDROXYMETHYLCYTOSINE; TET2; MYC;

D O I：

10.1038/nrc3781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The ability of stem cells to self-renew and generate different lineages during development and organogenesis is a fundamental, tightly controlled, and generally unidirectional process, whereas the 'immortality' of cancer cells could be regarded as pathological self-renewal. The molecular mechanisms that underpin the generation of induced pluripotent stem cells are remarkably similar to those that are deregulated in cancer-so much so that aberrant reprogramming is tumorigenic. The similarities also suggest that mutations in genes implicated in DNA methylation dynamics might represent a hallmark of cancers with a stem cell origin, and they highlight an alternative view of cancer that may be of clinical benefit.

引用

页码：568 / 573

页数：6

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