Membrane guanylyl cyclase receptors: an update

被引:87
作者
Garbers, David L. [1 ]
Chrisman, Ted D.
Wiegn, Phi
Katafuchi, Takeshi
Albanesi, Joseph P.
Bielinski, Vincent
Barylko, Barbara
Redfield, Margaret M.
Burnett, John C., Jr.
机构
[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Howard Hughes Med Inst,Cecil H & Ida Green Ctr Re, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Div Cardiol, Dept Internal Med, Dallas, TX 75390 USA
[3] Mayo Clin & Mayo Fdn, Cardiorenal Res Lab, Div Cardiovasc Dis, Rochester, MN 55905 USA
关键词
D O I
10.1016/j.tem.2006.06.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. Additionally, cell differentiation, and even tumor progression, can be profoundly influenced by one or more of these receptors. Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na+ balance.
引用
收藏
页码:251 / 258
页数:8
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