Mechanism of pineal-specific gene expression: The role of E-box and photoreceptor conserved elements

被引：28

作者：

Appelbaum, Lior

Gothilf, Yoav ^{[1
]}

机构：

[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel

[3] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 252卷 / 1-2期

关键词：

pineal; scrotonin-N-acetyltransferase; melatonin; photoreceptor; retina; zebrafish;

D O I：

10.1016/j.mce.2006.03.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Photoreceptor cells of the pineal gland express distinct sets of proteins dedicated to photoreception, phototransduction and to rhythmic melatonin production. This review discusses the function of key regulatory sequences and nuclear factors that determine tissue-restricted expression of photoreceptor genes, specifically, the photoreceptor conserved element (PCE) and the E-box and their cognate binding proteins. Recent research in zebrafish revealed that PCE and E-box mediate the action of OTX5 and BMAL/CLOCK, respectively. These transcription factors drive enhanced expression of serotonin-N-acetyltransferase-2 (aanat2) in the pineal gland by synergistic interaction. Extensive research of other photoreceptor-specific genes suggested that the presence of several PCEs along with additional sequence elements is required to drive enhanced tissue-specific expression of these genes. Therefore, the mechanism identified for zebrafish aanat2, or at least part of it, may apply to other photoreceptor-specific genes in zebrafish and other species. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 33

页数：7

共 55 条

[41] The mammalian Crx genes are highly divergent representatives of the Otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment [J].