Customizing the targeting of IGF-1 receptor

被引：45

作者：

Baserga, Renato ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

FUTURE ONCOLOGY | 2009年 / 5卷 / 01期

关键词：

anchorage independence; biomarkers; IGF-1; receptor; IRS-1; metastases; GROWTH-FACTOR-RECEPTOR; FACTOR-I RECEPTOR; INSULIN-LIKE-GROWTH-FACTOR-1; RECEPTOR; INSULIN-RECEPTOR-SUBSTRATE-1; IRS-1; NUCLEAR TRANSLOCATION; COLORECTAL-CANCER; UVEAL MELANOMA; ANTISENSE RNA; TUMOR-GROWTH; INSULIN;

D O I：

10.2217/14796694.5.1.43

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials. Targeting of the IGF-IR in cancer cells (by antibodies or other means) can be improved by the appropriate select ion of responsive tumors. This review focuses on the optimization of IGF-IR targeting in human cancer.

引用

页码：43 / 50

页数：8

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