Solid-phase synthesis of lipidated peptides

被引：47

作者：

Ludolph, B ^{[1
]}

Eisele, F ^{[1
]}

Waldmann, H ^{[1
]}

机构：

[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 21期

关键词：

D O I：

10.1021/ja025768t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after appropriate deprotection of cysteine thiol groups as the key steps. Copyright © 2002 American Chemical Society.

引用

页码：5954 / 5955

页数：2

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