Solid-phase synthesis of lipidated peptides

被引:47
作者
Ludolph, B [1 ]
Eisele, F [1 ]
Waldmann, H [1 ]
机构
[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany
关键词
D O I
10.1021/ja025768t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after appropriate deprotection of cysteine thiol groups as the key steps. Copyright © 2002 American Chemical Society.
引用
收藏
页码:5954 / 5955
页数:2
相关论文
共 21 条
[21]   Synthesis of characteristic lipopeptides of the human N-Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase [J].
Stober, P ;
Schelhaas, M ;
Nagele, E ;
Hagenbuch, P ;
Retey, J ;
Waldmann, H .
BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (01) :75-83