共 21 条
Solid-phase synthesis of lipidated peptides
被引:47
作者:
Ludolph, B
[1
]
Eisele, F
[1
]
Waldmann, H
[1
]
机构:
[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany
关键词:
D O I:
10.1021/ja025768t
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after appropriate deprotection of cysteine thiol groups as the key steps. Copyright © 2002 American Chemical Society.
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页码:5954 / 5955
页数:2
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