Electrolytic partial fluorination of organic compounds.: Part 61:: The first example of direct α-fluorination of protected α-amino acids

被引：24

作者：

Baba, D ^{[1
]}

Fuchigami, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Elect Chem, Midori Ku, Yokohama, Kanagawa 2268502, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(02)00924-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective anodic alpha-monofluorination of oxazolidines I derived from a-amino acid was successfully carried out. This is the first example of (lie successful, direct alpha-fluorination of protected amino acids. Anodic fluorination of methyl N-acetyl pyroglutamate also provided the corresponding alpha-fluorinated product in moderate yield, while the anodic fluorination of an open-chain alpha-amino acid. N-(carboethoxy)methlphathalimide, was unsuccessful. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4805 / 4808

页数：4

共 17 条

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