Natural killer cell-based immunotherapy in cancer: current insights and future prospects

被引：152

作者：

Sutlu, T. ^{[1
]}

Alici, E. ^{[1
]}

机构：

[1] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Div Haematol,Dept Med, Stockholm, Sweden

来源：

JOURNAL OF INTERNAL MEDICINE | 2009年 / 266卷 / 02期

关键词：

cancer immunotherapy; clinical trials; cytokines; ex vivo expansion; gene therapy; natural killer cells; ACUTE MYELOID-LEUKEMIA; LOW-DOSE INTERLEUKIN-2; CHRONIC MYELOGENOUS LEUKEMIA; EFFICIENT GENE-TRANSFER; REGULATORY T-CELLS; EX-VIVO EXPANSION; TUMOR-INFILTRATING LYMPHOCYTES; COLONY-STIMULATING FACTOR; NKG2D LIGAND EXPRESSION; BLOOD MONONUCLEAR-CELLS;

D O I：

10.1111/j.1365-2796.2009.02121.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell-based immunotherapeutic approaches in cancer starting from a historical background and an overview of molecular mechanisms taking part in NK cell responses. The status of NK cells in cancer patients, currently investigated clinical applications such as in vivo modulation of NK cell activity, ex vivo purification/expansion and adoptive transfer as well as future possibilities such as genetic modifications are discussed in detail.

引用

页码：154 / 181

页数：28

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