Antitumor and immunomodulatory effects of a water-soluble polysaccharide from Lilii Bulbus in mice

被引：84

作者：

Sun, Xin ^{[1
]}

Gao, Rui-Lan ^{[2
]}

Xiong, Yao-Kang ^{[3
]}

Huang, Qing-Cheng ^{[3
]}

Xu, Min ^{[4
]}

机构：

[1] Zhejiang Prov Peoples Hosp, Dept Oncol, Hangzhou 310024, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp TCM, Inst Hematol, Hangzhou 310006, Zhejiang, Peoples R China

[3] Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China

[4] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp TCM, Dept Pharm, Hangzhou 310006, Zhejiang, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2014年 / 102卷

基金：

中国国家自然科学基金;

关键词：

Characterization; Antitumor; Immunomodulatory; Lung carcinoma; TUMOR-INFILTRATING LYMPHOCYTES; BROWNII VAR. VIRIDULUM; TNF-ALPHA; CHEMOTHERAPEUTIC-AGENTS; ANTIOXIDANT ACTIVITIES; CYTOKINE RECEPTORS; LUNG-CARCINOMA; IN-VIVO; CANCER; APOPTOSIS;

D O I：

10.1016/j.carbpol.2013.12.002

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Lilii Bulbus is a popular folk medicine in the worldwide and has attracted great attention due to its bioactivity against respiratory system diseases (include lung cancers). This study was the first report providing in vivo evidences of antitumor potential of the bioactive polysaccharide from Lilii Bulbus. One major fraction (LBP-1) was obtained by purifying the crude polysaccharides extracted from Lilii Bulbus. Chemical characterization analysis indicated that LBP-1 was only a glucan, whose average molecular weight was 30.5 kDa. Intraperitoneal administration of LBP-1 at the doses of 50-200 mg/kg significantly inhibited the growth of Lewis lung carcinoma. Moreover, it could also obviously increase macrophage phagocytosis, splenocytes proliferation and cytokine (TNF-alpha, 1L-2, IL-6 and IL-12) production to participate in the antitumor effects. LBP-1 could act as antitumor agent with immunomodulatory activity. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：543 / 549

页数：7

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