Interleukin-18: The Bouncer at the Mucosal Bar

被引：29

作者：

Hand, Timothy W. ^{[1
]}

机构：

[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Richard King Mellon Inst Pediat Res, Pittsburgh, PA 15224 USA

来源：

CELL | 2015年 / 163卷 / 06期

关键词：

INFLAMMASOME; HOMEOSTASIS; RESPONSES;

D O I：

10.1016/j.cell.2015.11.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The fidelity of the intestinal barrier is critical to maintaining a healthy relationship between the immune system and the microbiota. Levy et al. and Nowarski et al. reveal how microbiota-derived metabolites modulate the activation of the inflammasome to influence the expression of the cytokine IL-18, intestinal barrier function, and intestinal inflammation.

引用

收藏

页码：1310 / U106

页数：3

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