Cardiovascular biology of the asymmetric dimethylarginine: Dimethylarginine dimethylaminohydrolase pathway

被引：470

作者：

Vallance, P ^{[1
]}

Leiper, J ^{[1
]}

机构：

[1] UCL, Rayne Inst, Div Med, BHF Labs, London WC1 6JJ, England

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2004年 / 24卷 / 06期

关键词：

asymmetric dimethylarginine; dimethylarginine dimethylaminohydrolase; nitric oxide synthase; endothelial dysfunction;

D O I：

10.1161/01.ATV.0000128897.54893.26

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An increasing number of reports indicate that endogenously produced inhibitors of nitric oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.

引用

页码：1023 / 1030

页数：8

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