Cardiovascular biology of the asymmetric dimethylarginine: Dimethylarginine dimethylaminohydrolase pathway

被引:470
作者
Vallance, P [1 ]
Leiper, J [1 ]
机构
[1] UCL, Rayne Inst, Div Med, BHF Labs, London WC1 6JJ, England
关键词
asymmetric dimethylarginine; dimethylarginine dimethylaminohydrolase; nitric oxide synthase; endothelial dysfunction;
D O I
10.1161/01.ATV.0000128897.54893.26
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An increasing number of reports indicate that endogenously produced inhibitors of nitric oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.
引用
收藏
页码:1023 / 1030
页数:8
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