Factors influencing the reverse-Cope approach to 1,2,5-oxadiazinanes from allylamines and nitrones: Optimization of a new vicinal diamine synthesis

被引：32

作者：

Bell, KE

Coogan, MP

Gravestock, MB

Knight, DW

Thornton, SR

机构：

[1] UNIV NOTTINGHAM, DEPT CHEM, NOTTINGHAM NG7 2RD, ENGLAND

[2] ZENECA PHARMACEUT, MACCLESFIELD SK10 4TJ, CHESHIRE, ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 49期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)10243-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nitrones generated from formaldehyde and N-alkyl-hydroxylamines are particularly suitable reactants in tandem reverse-Cope-Meisenheimer reactions leading to oxadiazinanes and thence N-hydroxydiamines and vicinal diamines, front allylamines. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：8545 / 8548

页数：4

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