N-alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines .8. the scope of tandem reactions involving hydroxylamine-alkyne cyclisations

被引:35
作者
Davison, EC
Forbes, IT
Holmes, AB
Warner, JA
机构
[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND
关键词
D O I
10.1016/0040-4020(96)00643-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A tandem sequence of hydroxylamine-alkyne cyclisation/1,3-dipolar cycloaddition, provides useful entry into tricyclic systems of type 4. The scope of such reactions is explored in this paper. A novel cascade cyclisation of N-hydroxypyrrolidines of type 26 and 28 involving hydroxylamine-alkyne cyclisation, Cope elimination and 1,3-dipolar cycloaddition is also reported. Copyright (C) 1996 Elsevier Science Ltd
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页码:11601 / 11624
页数:24
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