DNA demethylation by DNA repair

被引：187

作者：

Gehring, Mary ^{[1
]}

Reik, Wolf ^{[2
]}

Henikoff, Steven ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA

[2] Babraham Inst, Lab Dev Genet & Imprinting, Cambridge CB22 3AT, England

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

BASE-EXCISION-REPAIR; PRIMORDIAL GERM-CELLS; REGULATED GADD45 PROTEIN; PREIMPLANTATION DEVELOPMENT; ESCHERICHIA-COLI; 5-METHYLCYTOSINE-DNA GLYCOSYLASE; CYTOSINE METHYLTRANSFERASES; MAMMALIAN DEVELOPMENT; METHYLATION PATTERNS; PATERNAL GENOME;

D O I：

10.1016/j.tig.2008.12.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achieving it remain murky and mammals lack counterparts to the plant demethylases. Several intriguing experiments have indicated, but not conclusively proven, that DNA repair is also a plausible mechanism for animal demethylation. Here, we examine what is known from flowering plants about the pathways and function of enzymatic demethylation and discuss possible mechanisms whereby DNA repair might also underlie global demethylation in mammals.

引用

页码：82 / 90

页数：9

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