Structural organization and chromosomal assignment of the swine endothelin-1 gene

被引：3

作者：

Kojima, M ^{[1
]}

Ohata, K ^{[1
]}

Hiroshi, Y ^{[1
]}

机构：

[1] UNIV TSUKUBA,TSUKUBA,IBARAKI 305,JAPAN

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1997年 / 59卷 / 06期

关键词：

EDNI; FISH; gene structure; mapping; swine;

D O I：

10.1292/jvms.59.431

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Cosmid clone containing swine endothelin-1 (EDN1) gene, cosEDN1, was isolated from swine cosmid library using swine EDN1 cDNA as a probe. The sequence analysis of cosEDN1 DNA revealed that the swine EDN1 gene consists of 5 exons, spanning approximately 6.5 kb. In the 5'-upstream region of the EDN1 gene, AP-1 and NF-1 elements were found, suggesting the possibility that the expression of swine EDN1 gene is controlled by protooncogene products Fos and Jun, and TGF-beta. Fluorescence in situ hybridization (FISH) using cosEDN1 DNA as a probe demonstrated that EDN1 gene resides on swine chromosome 7p13->pter.

引用

页码：431 / 435

页数：5

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