Regulation of cutaneous allergic reaction by odorant inhalation

被引：7

作者：

Hosoi, J ^{[1
]}

Tsuchiya, T ^{[1
]}

机构：

[1] Life Sci Res Ctr, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2000年 / 114卷 / 03期

关键词：

glucocorticoide; Langerhans cell;

D O I：

10.1046/j.1523-1747.2000.00896.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Olfactory stimuli modulate emotional conditions and the whole body immune system. Effects of odorant inhalation on cutaneous immune reaction were examined. Contact hypersensitivity to 2,4,6-trinitrochlorobenzene was elicited in C57BL/6 mice. The reaction was suppressed at both the induction and elicitation phases by exposure to an odorant, citralva. Topical application of citralva or lyral/lilial did not affect the reaction. The suppressive effect of citralva was more potent than that of another odorant, lyral/lilial. Citralva decreased the number of epidermal Langerhans cells, whereas lyral/lilial had a weak effect. Citralva but not lyral/lilial induced plasma corticosterone. Glucocorticoid receptor antagonist abrogated the suppressive effect of citralva on contact hypersensitivity. Serum interleukin-12 was downregulated by exposure to citralva or lyral/lilial. These data demonstrate that olfactory stimuli regulate the cutaneous immune system.

引用

页码：541 / 544

页数：4

共 17 条

[11] The expanding universe of T-cell subsets: Th1, Th2 and more [J].