Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

被引：160

作者：

Estrada, K. M.

Clay, C. M.

Pompolo, S.

Smith, J. T.

Clarke, I. J.

机构：

[1] Monash Univ, Dept Physiol, Monash, Vic 3800, Australia

[2] Prince Henrys Inst Med Res, Clayton, Vic, Australia

[3] Colorado State Univ, Dept Physiol, Ft Collins, CO 80523 USA

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2006年 / 18卷 / 10期

关键词：

hypothalamus; oestrous cycle; oestrogen receptor;

D O I：

10.1111/j.1365-2826.2006.01485.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.

引用

收藏

页码：806 / 809

页数：4

相关论文

共 28 条

[1] Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts [J].

Bilban, M ;

Ghaffari-Tabrizi, N ;

Hintermann, E ;

Bauer, S ;

Molzer, S ;

Zoratti, C ;

Malli, R ;

Sharabi, A ;

Hiden, U ;

Graier, W ;

Knöfler, M ;

Andreae, F ;

Wagner, O ;

Quaranta, V ;

Desoye, G .

JOURNAL OF CELL SCIENCE, 2004, 117 (08) :1319-1328

[2] VENTROMEDIAL HYPOTHALAMUS AS A TARGET FOR ESTRADIOL ACTION ON PROCEPTIVITY, RECEPTIVITY AND LUTEINIZING-HORMONE SURGE OF THE EWE [J].

BLACHE, D ;

FABRENYS, CJ ;

VENIER, G .

BRAIN RESEARCH, 1991, 546 (02) :241-249

[3] KiSS-1 expression and metastin-like immunoreactivity in the rat brain [J].

Brailoiu, GC ;

Dun, SL ;

Ohsawa, M ;

Yin, DL ;

Yang, J ;

Chang, JK ;

Brailoiu, E ;

Dun, NJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 2005, 481 (03) :314-329

[4] Evidence that the mediobasal hypothalamus is the primary site of action of estradiol in inducing the preovulatory gonadotropin releasing hormone surge in the ewe [J].

Caraty, A ;

Fabre-nys, C ;

Delaleu, B ;

Locatelli, A ;

Bruneau, G ;

Karsch, FJ ;

Herbison, A .

ENDOCRINOLOGY, 1998, 139 (04) :1752-1760

[5]

CLARKE IJ, 1995, TRENDS ENDOCRIN MET, V7, P637

[6] SECRETION OF PROLACTIN AND LUTEINIZING-HORMONE AT ESTRUS IN EWE [J].

CUMMING, IA ;

BRYANT, GD ;

BROWN, JM ;

GODING, JR ;

GREENWOOD, FC .

JOURNAL OF ENDOCRINOLOGY, 1972, 54 (02) :207-+

[7] Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 [J].

de Roux, N ;

Genin, E ;

Carel, JC ;

Matsuda, F ;

Chaussain, JL ;

Milgrom, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10972-10976

[8] Neuropeptide Y (NPY) delays the oestrogen-induced luteinizing hormone (LH) surge in the ovariectomized ewe: Further evidence that NPY has a predominant negative effect on LH secretion in the ewe [J].

Estrada, KM ;

Pompolo, S ;

Morris, MJ ;

Tilbrook, AJ ;

Clarke, IJ .

JOURNAL OF NEUROENDOCRINOLOGY, 2003, 15 (11) :1011-1020

[9] Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha [J].

Franceschini, I. ;

Lomet, D. ;

Cateau, M. ;

Delsol, G. ;

Tillet, Y. ;

Caraty, A. .

NEUROSCIENCE LETTERS, 2006, 401 (03) :225-230

[10] The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system [J].

Funes, S ;

Hedrick, JA ;

Vassileva, G ;

Markowitz, L ;

Abbondanzo, S ;

Golovko, A ;

Yang, SJ ;

Monsma, FJ ;

Gustafson, EL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 312 (04) :1357-1363