Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

被引：44

作者：

Kuwabara, Junpei ^{[1
]}

Sakai, Masaru ^{[1
]}

Zhang, Qiao ^{[1
]}

Kanbara, Takaki ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Pure & Appl Sci, Tsukuba Res Ctr Interdisciplinary Mat Sci TIMS, Tsukuba, Ibaraki 3058573, Japan

来源：

ORGANIC CHEMISTRY FRONTIERS | 2015年 / 2卷 / 05期

关键词：

RECENT PROGRESS; PALLADIUM; COMPLEXES; TRANSMETALATION; ARYLPALLADIUM; HETEROARENES; REDUCTION;

D O I：

10.1039/c4qo00351a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The initial step of a Pd-catalysed phosphine-free direct arylation reaction was investigated to provide mechanistic insight, leading to optimisation of the catalytic reaction. On the basis of our observations, the amount of the Pd(OAc)(2) catalyst was reduced to 1 mol%, affording a good yield of the desired product in combination with a reduction in the amount of by-products.

引用

页码：520 / 525

页数：6

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