The exosome:: a macromolecular cage for controlled RNA degradation

被引:41
作者
Buettner, Katharina
Wenig, Katja
Hopfner, Karl-Peter
机构
[1] Univ Munich, Gene Ctr, D-81377 Munich, Germany
[2] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
关键词
D O I
10.1111/j.1365-2958.2006.05331.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The exosome, a large multisubunit complex with exoribonucleic activity, emerges as the central 3' RNA degradation and processing factor in eukaryotes and archaea. But how are the many RNA substrates of the exosome degraded in a processive, yet controlled manner? Recent functional and structural progress shows that the exosome is a macromolecular cage, where the nuclease active sites are situated in a central processing chamber. A narrow entry pore controls access to the active sites in the processing chamber and prevents uncontrolled RNA decay. The emerging mechanism of exosome function suggests a strikingly parallel architectural concept to protein degradation by proteasomes.
引用
收藏
页码:1372 / 1379
页数:8
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