Perspectives on Tuberculosis Pathogenesis and Discovery of Anti-Tubercular Drugs

被引：7

作者：

Ntie-Kang, Fidele ^{[1
,2
,3
]}

Yong, Joseph N. ^{[4
]}

Owono, Luc C. Owono ^{[1
,5
]}

Sippl, Wolfgang ^{[3
]}

Megnassan, Eugene ^{[6
]}

机构：

[1] Univ Douala, Fac Sci, CEPAMOQ, Douala, Cameroon

[2] Univ Buea, Fac Sci, Dept Chem, Chem & Bioact Informat Ctr, Buea, Cameroon

[3] Univ Halle Wittenberg, Dept Pharmaceut Sci, D-06120 Halle, Saale, Germany

[4] Univ Buea, Fac Sci, Dept Chem, Buea, Cameroon

[5] Univ Yaounde I, Ecole Normale Super, Lab Simulat & Biomol Phys, Yaounde, Cameroon

[6] Univ Abobo Adjame, Lab Fundamental & Appl Phys, Abidjan, Cote Ivoire

来源：

CURRENT MEDICINAL CHEMISTRY | 2014年 / 21卷 / 30期

关键词：

Drug discovery; drug resistance; in silico screening; tuberculosis; HIGH-THROUGHPUT DOCKING; MYCOBACTERIUM-TUBERCULOSIS; NATURAL-PRODUCTS; IN-VITRO; ANTIMYCOBACTERIAL ACTIVITY; COMBINATORIAL CHEMISTRY; ASPARTIC PROTEASE; POTENT INHIBITORS; THYMIDINE ANALOGS; MEDICINAL-PLANTS;

D O I：

10.2174/0929867321666140706144933

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on the global burden of tuberculosis and resistant strains that have recently emerged, not responding to existing therapies, it has become urgent to search for new remedies against this global human plague that has been compounded by HIV co-infection. Thus, the search for new drugs against the disease-causing agent, Mycobacterium tuberculosis (MTB), is an ongoing effort. This review discusses the state-of-the-art in anti-tuberculosis pathogenesis and anti-TB drug research, identifying some of the challenges being faced by researchers in the field and sheds light on possible ways forward, particularly in low-income countries.

引用

页码：3466 / 3477

页数：12

共 153 条

[1] High-throughput docking for lead generation [J].