Trends in the Molecular Pathogenesis and Clinical Therapeutics of Common Neurodegenerative Disorders

被引:68
作者
Choonara, Yahya E. [1 ]
Pillay, Viness [1 ]
du Toit, Lisa C. [1 ]
Modi, Girish [2 ]
Naidoo, Dinesh [3 ]
Ndesendo, Valence M. K. [1 ]
Sibambo, Sibongile R. [1 ]
机构
[1] Univ Witwatersrand, Dept Pharm & Pharmacol, ZA-2193 Johannesburg, South Africa
[2] Univ Witwatersrand, Dept Neurol, ZA-2193 Johannesburg, South Africa
[3] Univ Witwatersrand, Dept Neurosurg, ZA-2193 Johannesburg, South Africa
来源
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 06期
关键词
Parkinson's disease; Alzheimer's disease; Amyotrophic Lateral Sclerosis; Huntington's disease; neuropathology; amyloid-beta protein; Tau; Huntingtin; alpha-Synuclein; neurotherapeutics; drug delivery; AMYOTROPHIC-LATERAL-SCLEROSIS; MILD COGNITIVE IMPAIRMENT; AMYLOID-PRECURSOR-PROTEIN; NEURAL PROGENITOR CELLS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; HUNTINGTONS-DISEASE; A-BETA; STEM-CELLS;
D O I
10.3390/ijms10062510
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The term neurodegenerative disorders, encompasses a variety of underlying conditions, sporadic and/or familial and are characterized by the persistent loss of neuronal subtypes. These disorders can disrupt molecular pathways, synapses, neuronal subpopulations and local circuits in specific brain regions, as well as higher-order neural networks. Abnormal network activities may result in a vicious cycle, further impairing the integrity and functions of neurons and synapses, for example, through aberrant excitation or inhibition. The most common neurodegenerative disorders are Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis and Huntington's disease. The molecular features of these disorders have been extensively researched and various unique neurotherapeutic interventions have been developed. However, there is an enormous coercion to integrate the existing knowledge in order to intensify the reliability with which neurodegenerative disorders can be diagnosed and treated. The objective of this review article is therefore to assimilate these disorders' in terms of their neuropathology, neurogenetics, etiology, trends in pharmacological treatment, clinical management, and the use of innovative neurotherapeutic interventions.
引用
收藏
页码:2510 / 2557
页数:48
相关论文
共 278 条
[1]   Symptomatic treatment of Huntington disease [J].
Adam, Octavian R. ;
Jankovic, Joseph .
NEUROTHERAPEUTICS, 2008, 5 (02) :181-197
[2]   Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment [J].
Ahmed, N ;
Ahmed, U ;
Thornalley, PJ ;
Hager, K ;
Fleischer, G ;
Münch, G .
JOURNAL OF NEUROCHEMISTRY, 2005, 92 (02) :255-263
[3]   Inflammation and Alzheimer's disease [J].
Akiyama, H ;
Barger, S ;
Barnum, S ;
Bradt, B ;
Bauer, J ;
Cole, GM ;
Cooper, NR ;
Eikelenboom, P ;
Emmerling, M ;
Fiebich, BL ;
Finch, CE ;
Frautschy, S ;
Griffin, WST ;
Hampel, H ;
Hull, M ;
Landreth, G ;
Lue, LF ;
Mrak, R ;
Mackenzie, IR ;
McGeer, PL ;
O'Banion, MK ;
Pachter, J ;
Pasinetti, G ;
Plata-Salaman, C ;
Rogers, J ;
Rydel, R ;
Shen, Y ;
Streit, W ;
Strohmeyer, R ;
Tooyoma, I ;
Van Muiswinkel, FL ;
Veerhuis, R ;
Walker, D ;
Webster, S ;
Wegrzyniak, B ;
Wenk, G ;
Wyss-Coray, T .
NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421
[4]   Initial agonist treatment of Parkinson disease - A critique [J].
Albin, RL ;
Frey, KA .
NEUROLOGY, 2003, 60 (03) :390-394
[5]  
*AM PSYCH ASS DSM, 1994, DIAGN STAT MAN
[6]   Incidence and predictors of seizures in patients with Alzheimer's disease [J].
Amatniek, JC ;
Hauser, WA ;
DelCastillo-Castaneda, C ;
Jacobs, DM ;
Marder, K ;
Bell, K ;
Albert, M ;
Brandt, J ;
Stern, Y .
EPILEPSIA, 2006, 47 (05) :867-872
[7]   Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes [J].
Andersen, PM ;
Sims, KB ;
Xin, WW ;
Kiely, R ;
O'Neill, G ;
Ravits, J ;
Pioro, E ;
Harati, Y ;
Brower, RD ;
Levine, JS ;
Heinicke, HU ;
Seltzer, W ;
Boss, M ;
Brown, RH .
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2003, 4 (02) :62-73
[8]   Cost of disorders of the brain in Europe [J].
Andlin-Sobocki, P ;
Jönsson, B ;
Wittchen, HU ;
Olesen, J .
EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 :1-+
[9]   HEAT REPEATS IN THE HUNTINGTONS-DISEASE PROTEIN [J].
ANDRADE, MA ;
BORK, P .
NATURE GENETICS, 1995, 11 (02) :115-116
[10]   A cell biological perspective on Alzheimer's disease [J].
Annaert, W ;
De Strooper, B .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2002, 18 :25-51