Divide and conquer: the importance of cell division in regulating B-cell responses

被引：95

作者：

Tangye, SG

Hodgkin, PD

机构：

[1] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

[2] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia

来源：

IMMUNOLOGY | 2004年 / 112卷 / 04期

关键词：

antibody responses; B cells; cell division; Ig secretion; lymphocyte differentiation;

D O I：

10.1111/j.1365-2567.2004.01950.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Proliferation is an essential characteristic of clonal selection and is required for the expansion of antigen reactive clones leading to the development of antibody of different isotypes and memory cells. New data for mouse and human B cells point to an important role for division in regulating isotype class and in optimizing development of protective immunity by the regulated entry of cells to the plasma cell lineage.

引用

页码：509 / 520

页数：12

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