Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment

被引：85

作者：

Barim, Abdullah Onder ^{[1
]}

Aydin, Suleyman ^{[1
]}

Colak, Ramis ^{[2
]}

Dag, Ersel ^{[3
]}

Deniz, Omer ^{[4
]}

Sahin, Ibrahim ^{[1
]}

机构：

[1] Firat Univ, Sch Med, Firat Univ Hosp,Firat Hormone Res Grp, Dept Med Biochem & Clin Biochem, TR-23119 Elazig, Turkey

[2] Firat Univ, Sch Med, Firat Univ Hosp, Dept Endocrinol & Metab Dis Internal Med, TR-23119 Elazig, Turkey

[3] Elazig Res & Educ Hosp, Dept Neurol, TR-23119 Elazig, Turkey

[4] Elazig Mental Disorders Hosp, TR-23100 Elazig, Turkey

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期

关键词：

Ghrelin; Paraoxonase; Arylesterase; Major depression; LOW SERUM-CHOLESTEROL; HDL-CHOLESTEROL; ANTIOXIDANT; LIPOPROTEINS; HORMONE; PROFILE;

D O I：

10.1016/j.clinbiochem.2009.02.020

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: The purpose of this study was to examine alterations in lipid profiles and in the serum concentrations of acylated and desacylated ghrelin, paraoxonase and arylesterase in psychiatric patients before and after treatment with 40 mg citalopram daily for 3 months. Design and methods: Samples were collected from 22 healthy controls and 24 psychiatric patients before and after citalopram treatment. Blood levels of acylated and desacylated ghrelin were measured by radioimmunoassay. Paraoxonase and arylesterase activities were determined spectrophotometrically. Lipid parameters were measured on the OLYMPUS-AU400. Results: It was found that the levels of acylated, desacylated ghrelin, paraoxonase arylesterase, total cholesterol and triglyceride were lower in depressive patients before citalopram treatment than in the control group. Those parameters were not restored after citalopram treatment except for the arylesterase level. Conclusion: Decreased PON1 and ghrelin levels as well as fluctuations in lipid profiles may be involved in the etiology of depressive disorders. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1076 / 1081

页数：6

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