共 18 条
Prostaglandin H2 (PGH2) accelerates formation of amyloid β1-42 oligomers
被引:54
作者:

Boutaud, O
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA

Ou, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA

Chaurand, P
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA

Caprioli, RM
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA

Montine, TJ
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA

Oates, JA
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA
机构:
[1] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA
[2] Vanderbilt Univ, Ctr Mol Neurosci, Nashville, TN USA
[3] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Mass Spectrometry Res Ctr, Dept Pathol, Nashville, TN USA
[5] Vanderbilt Univ, Mass Spectrometry Res Ctr, Dept Med, Nashville, TN USA
关键词:
Alzheimer;
amyloid;
cyclooxygenase;
levuglandin;
oligomer;
D O I:
10.1046/j.1471-4159.2002.01064.x
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Epidemiologic evidence implicates cyclooxygenase activity in the pathogenesis of Alzheimer's disease, in which amyloid plaques have been found to contain increased levels of dimers and higher multimers of the amyloid beta peptide. The product of the oxygenation of arachidonic acid by the cyclooxygenases, prostaglandin H-2 (PGH(2) ), rearranges non-enzymatically to several prostaglandins, including the highly reactive gamma-keto aldehydes, levuglandins E-2 and D-2 . We demonstrate that PGH(2) markedly accelerates the formation of dimers and higher oligomers of amyloid beta(1-42) . This is associated with the formation of levuglandin adducts of the peptide. These findings provide the molecular basis for a hypothesis linking cyclooxygenase activity to the formation of oligomers of amyloid beta.
引用
收藏
页码:1003 / 1006
页数:4
相关论文
共 18 条
- [1] Characterization of copper interactions with Alzheimer amyloid β peptides:: Identification of an attomolar-affinity copper binding site on amyloid β1-42[J]. JOURNAL OF NEUROCHEMISTRY, 2000, 75 (03) : 1219 - 1233Atwood, CS论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USAScarpa, RC论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USAHuang, XD论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USAMoir, RD论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USAJones, WD论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USAFairlie, DP论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USATanzi, RE论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USABush, AI论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Dept Psychiat, Lab Oxidat Biol, Boston, MA 02114 USA
- [2] Formation of highly reactive γ-ketoaldehudes (Neuroketals) as products of the neuroprostane pathway[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (33) : 30964 - 30970Bernoud-Hubac, N论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USADavies, SS论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USABoutaud, O论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USAMontine, TJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USARoberts, LJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
- [3] Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid[J]. BIOCHEMISTRY, 2001, 40 (23) : 6948 - 6955Boutaud, O论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USABrame, CJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USAChaurand, P论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USALi, JY论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USARowlinson, SW论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USACrews, BC论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USAJi, C论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USAMarnett, LJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USACaprioli, RM论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USARoberts, LJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USAOates, JA论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
- [4] Identification of extremely reactive γ-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) : 13139 - 13146Brame, CJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USASalomon, RG论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USAMorrow, JD论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USARoberts, LJ论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
- [5] Do nonsteroidal antiinflammatory drugs reduce the risk of Alzheimer's disease?[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (21) : 1567 - 1568Breitner, JCS论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Baltimore, MD 21205 USA Johns Hopkins Univ, Baltimore, MD 21205 USAZandi, PP论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Baltimore, MD 21205 USA Johns Hopkins Univ, Baltimore, MD 21205 USA
- [6] Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct[J]. SCIENCE, 2001, 294 (5545) : 1346 - 1349Conway, KA论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USARochet, JC论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USABieganski, RM论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USALansbury, PT论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
- [7] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) : 885 - 890GLENNER, GG论文数: 0 引用数: 0 h-index: 0WONG, CW论文数: 0 引用数: 0 h-index: 0
- [8] Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (21) : 1515 - 1521in 't Veld, BA论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, NetherlandsRuitenberg, A论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, NetherlandsHofman, A论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, NetherlandsLauner, LJ论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlandsvan Duijn, CM论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, NetherlandsStijnen, T论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, NetherlandsBreteler, MMB论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, NetherlandsStricker, BHC论文数: 0 引用数: 0 h-index: 0机构: Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands
- [9] GENERATION OF PYRROLES IN THE REACTION OF LEVUGLANDIN E(2) WITH PROTEINS[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (20) : 6038 - 6043IYER, RS论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USAKOBIERSKI, ME论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USASALOMON, RG论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA
- [10] LEVUGLANDIN-E2 CROSSLINKS PROTEINS[J]. PROSTAGLANDINS, 1989, 37 (04): : 471 - 480IYER, RS论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106GHOSH, S论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106SALOMON, RG论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106