Cancer stem cells: mirage or reality?

被引：747

作者：

Gupta, Piyush B. ^{[2
]}

Chaffer, Christine L. ^{[1
,3
]}

Weinberg, Robert A. ^{[1
,3
,4
]}

机构：

[1] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA

[2] Massachusetts Inst Technol & Harvard, Broad Inst, Cambridge, MA USA

[3] MIT, Ludwig Ctr Mol Oncol, Cambridge, MA 02139 USA

[4] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 09期

关键词：

ACUTE MYELOID-LEUKEMIA; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; MOUSE MODEL; GROWTH; IDENTIFICATION; CARCINOMA; TUMORS; PROGRESSION; RESISTANCE;

D O I：

10.1038/nm0909-1010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The similarities and differences between normal tissue stem cells and cancer stem cells (CSCs) have been the source of much contention, with some recent studies calling into question the very existence of CSCs. An examination of the literature indicates, however, that the CSC model rests on firm experimental foundations and that differences in the observed frequencies of CSCs within tumors reflect the various cancer types and hosts used to assay these cells. Studies of stem cells and the differentiation program termed the epithelial-mesenchymal transition (EMT) point to the possible existence of plasticity between stem cells and their more differentiated derivatives. If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches.

引用

页码：1010 / 1012

页数：3

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