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MicroRNA signatures in human cancers

被引：6529
作者：
Calin, George A.
Croce, Carlo M. [1 ]
机构：
[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 11期
关键词：
D O I：
10.1038/nrc1997
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
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页码：857 / 866
页数：10
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