Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. II. Incidence of numerical and structural chromosomal aberrations in the lymphocytes

Cytogenetic studies using cord blood samples from newborns from high-level natural radiation areas of the Kerala coast in Southwest India have been in progress since 1986. A total of 963,940 metaphases from 10,230 newborns have been screened for various types of chromosomal aberrations. Comparison of 8,493 newborns (804,212 cells) from high-level natural radiation areas (dose rate >1.5 mGy/year) and 1,737 newborns (159,128 cells) from normal-level natural radiation areas (less than or equal to 1.5 mGy/year) did not show any significant difference in the frequency of dicentrics, translocations, inversions or other types of aberrations known to be associated with radiation exposure. The cytogenetic studies were continued for constitutional anomalies using karyotype analysis, and scoring of 16,169 newborns has been completed. The overall frequency of constitutional anomalies was 4.95 +/- 0.55 per 1,000 newborns, which is comparable to the incidence reported in the literature. Within the limitations of sample size, the frequencies of total autosomal and sex aneuploids as well as structural anomalies were comparable between the high-level and normal-level natural radiation areas. A striking observation was the presence of rogue cells, the rarely occurring metaphases with a high level of chromosomal damage, which have not been reported previously among newborns. (C) 1999 by Radiation Research Society.