Exposing the kinetic traps in RNA folding

被引：192

作者：

Treiber, DK

Williamson, JR

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(99)80045-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large ribozymes fold on a 'glacial' timescale compared to the folding of their protein counterparts. The sluggish folding exhibited by large RNAs results from the formation of kinetically trapped, misfolded intermediates, which are nonessential features of the folding mechanism, Newly developed mutant ribozymes that avoid kinetic traps should facilitate the study of the RNA folding problem.

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页码：339 / 345

页数：7

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