Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging

被引:79
作者
Beckers, NGM
Macklon, NS
Eijkemans, MJC
Fauser, BCJM
机构
[1] Erasmus MC, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands
[2] Erasmus MC, Dept Publ Hlth, NL-3015 GD Rotterdam, Netherlands
关键词
ovarian aging; IVF; poor response; follicular phase; follicles; FSH; progesterone; inhibin; ovary; menstrual cycle;
D O I
10.1016/S0015-0282(02)03227-2
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To investigate whether follicular phase characteristics associated with ovarian aging can be observed in women of normal reproductive age, who had previously shown a poor response to ovarian hyperstimulation for IVF. Design: Observational, prospective study. Setting: Tertiary fertility center. Patient(s): Eleven regularly cycling, ovulatory women, aged 29-40 years who previously presented with fewer than four dominant follicles after ovarian hyperstimulation for IVF. Intervention(s): Frequent serum hormone assessments and transvaginal ultrasound during the follicular phase of a spontaneous, unstimulated cycle. Main Outcome Measure(s): Duration of the follicular phase; serum LH, FSH, E-2, P, inhibin A, and inhibin B levels; and number of antral follicles observed by ultrasound. Results were compared with the cycle characteristics of a reference population of 38 healthy normo-ovulatory women aged 20-36 years (as published elsewhere). Result(s): Poor responders had significantly fewer antral follicles than controls. Median FSH concentrations were significantly higher compared with controls, but the majority had FSH levels within the normal range. Follicular phase P levels were significantly higher in poor responders. Duration of the follicular phase, E-2, and inhibin A and inhibin B serum levels did not differ between poor responders and controls. Conclusion(s): Normo-ovulatory regularly cycling women with a previous poor response to ovarian hyperstimulation for IVF show follicular phase characteristics suggestive of ovarian aging.
引用
收藏
页码:291 / 297
页数:7
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