beta-ketolases - Forgotten hydrolytic enzymes?

被引：26

作者：

Pokorny, D ^{[1
]}

Steiner, W ^{[1
]}

Ribbons, DW ^{[1
]}

机构：

[1] GRAZ UNIV, INST ORGAN CHEM, SFB BIOCATALYSIS, A-8010 GRAZ, AUSTRIA

来源：

TRENDS IN BIOTECHNOLOGY | 1997年 / 15卷 / 08期

关键词：

D O I：

10.1016/S0167-7799(97)01055-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

beta-Ketolases are a forgotten group of enzymes that hydrolyse carbon-carbon bonds of 1,3-diketones to give a cayboxylate anion and an alkyl ketone. They are ubiquitous and occupy a central catabolic role. We describe the physiological role of beta-ketolases and their potential application for kinetic resolution and synthesis. They are compared with heteroatom-bond hydrolases, which are essential to structural and synthetic chemists for the degradation of polymers and the synthesis of single-isomer substances. Will beta-ketolases be useful for carbon-carbon bond synthesis?

引用

页码：291 / 296

页数：6

共 42 条

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