Measurement of tacrolimus (FK506) and its metabolites: A review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies

被引:47
作者
Alak, AM
机构
[1] Fujisawa Res. Inst. of America, Inc., NW University/Evanston Research Park, Evanston, IL
[2] Fujisawa Res. Inst. of America, Inc., NW University/Evanston Research Park, Evanston, IL 60201-3135
关键词
FK506; metabolites; pharmacokinetics studies; tacrolimus; therapeutic drug monitoring;
D O I
10.1097/00007691-199706000-00016
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Tacrolimus (FK506, Prograf) is a macrolide immunosuppressant used for the prevention of organ rejection after transplantation. Tacrolimus demonstrates considerable interindividual variation in its pharmacokinetic profile. This has caused difficulty in defining the optimum regimen and has highlighted the need for therapeutic drug monitoring. Several assay methods for the measurements of tacrolimus in biological specimens have been developed. These assay methods were used for therapeutic drug monitoring and/or pharmacokinetic studies, Two commercially available immunoassays. based on the same monoclonal antibody to tacrolimus, have been used for therapeutic drug monitoring of tacrolimus in whole blood. For pharmacokinetic studies, the assay methods were used to measure tacrolimus and its metabolites in very low concentrations in selected biological matrixes to determine the metabolic and pharmacokinetic profiles of this drug.
引用
收藏
页码:338 / 351
页数:14
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