Novel Nonstatin Strategies to Lower Low-Density Lipoprotein Cholesterol

被引：37

作者：

Davidson, Michael H. ^{[1
]}

机构：

[1] Radiant Res, Chicago, IL 60654 USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2009年 / 11卷 / 01期

关键词：

TRIGLYCERIDE TRANSFER PROTEIN; APOLIPOPROTEIN-B; INHIBITOR; SPECTRUM; POTENT; LDL;

D O I：

10.1007/s11883-009-0011-0

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

There remains an unmet need to reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients who are maximized on current therapy or intolerant to statins. Several novel agents have been developed to lower LDL-C, either as monotherapy or in combination with statins. These novel therapies include squalene synthase inhibitors, microsomal triglyceride transfer protein inhibitors, and antisense apolipoprotein B. Although each of these novel therapies effectively lowers LDL-C, challenges remain in the clinical development to assess long-term safety.

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收藏

页码：67 / 70

页数：4

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